Smoking and depression can be linked to each other. An individual prefer smoking to get relief from depression and quitting it, become impossible as its adaptability by the brain for a long period of time. According to a new research, cigarette smoke has some anti-depressant properties as it contains thousands of chemicals besides nicotine, affecting the mood of person as same as done by anti-depressant medication also called monoamine oxidase inhibitors (MAOIs). Smoking is thus, done by depressed individuals to self-medicate themselves. A new medication called Bupropion (Zyban) -one of the safe as well as an effective anti-depressant for smoking, helps in reducing withdrawal symptoms, maintaining ideal weight and refreshing the mood of the patients.