Clozapine is the most effectual drug for the treatment of psychotic depression. The researchers of the University of Rochester Medical Centre have concluded a study, which showed that clopazine, has some side effects. This may cause some long-standing health problems. J. Steven Lamberti, the author of the study, said that clozapine increased the risk of metabolic syndrome. The metabolic syndrome further increases the risk for heart disease, stroke and diabetes. The American Journal of Psychiatry has published the detail of the study.